Ontology highlight
ABSTRACT:
SUBMITTER: Park SH
PROVIDER: S-EPMC4306257 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Park Sang Hyuk SH Choi Jae-Cheol JC Kim Shine Young SY Yi Jongyoun J Oh Seung Hwan SH Kim In-Suk IS Kim Hyung-Hoi HH Chang Chulhun Ludgerus CL Lee Eun Yup EY Song Moo-Kon MK Shin Ho-Jin HJ Chung Joo Seop JS
BioMed research international 20150111
<h4>Background</h4>DNA methyltransferase 3A (DNMT3A) mutation was recently introduced as a prognostic indicator in normal karyotype (NK) AML and we evaluated the incidence and prognostic impact of DNMT3A mutations in Korean NK AML patients.<h4>Methods</h4>Total 67 NK AML patients diagnosed during the recent 10 years were enrolled. DNMT3A mutations were analyzed by direct sequencing and categorized into nonsynonymous variations (NSV), deleterious mutations (DM), and R882 mutation based on in sili ...[more]