Dataset Information

Gender differences in preclinical markers of kidney injury in a rural north Carolina african-american cohort.

ABSTRACT:

Introduction

The incidence rate of end-stage renal disease (ESRD) is highest among African-American (AA) males. The reason for this disparity in ESRD for AA males remains unclear, but it is well established that diabetes is the leading risk factor. Prediabetes may also be a risk for kidney disease since prediabetics have increased risk for cardiovascular disease and often do not receive drug interventions unless their hemoglobin A1c (A1c) level is above 6%. Perhaps, AA males are at greater risk because they often are untreated prediabetics and this predisposes them to renal injury. Therefore, we hypothesize that prediabetic AA males have higher albumin:creatinine ratio (ACr), a biomarker of renal injury, than their female counterparts.

Methods

Male and female AAs were recruited (53 females and 47 males; 45?±?2?years old) from a rural northeastern region of NC. Blood and urine samples were collected for A1c and albumin measurements, respectively. Participants were stratified based on their A1c levels: non-diabetic: <5.7%, prediabetic: ?5.7% but <6.5%, and diabetic: ?6.5%.

Results

The proportion of males that are normal, prediabetic, and diabetic differed from that of females (p?=?0.002). Interestingly, prediabetic men tended to be younger (41?±?4 vs. 51?±?3, respectively; p?=?0.027) than prediabetic females (p?=?0.027). A1c and ACr were not associated with blood pressure in males or females. AA males had a relative risk of 0.9, 2.5, and 1.4 for microalbuminuria for non-diabetic, prediabetic, and diabetic, respectively, compared to AA females.

Conclusion

These results support our hypothesis that AA males may be predisposed to prediabetes kidney injury compared to their female counterpart. Thus, young AA males should be screened for biomarkers of kidney injury even if they have normal glucose and blood pressure levels.

SUBMITTER: Pointer MA

PROVIDER: S-EPMC4306298 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Gender differences in preclinical markers of kidney injury in a rural north Carolina african-american cohort.

Pointer Mildred A MA Hicks Kianda K Williams-Devane ClarLynda C Wells Candace C Greene Natasha N

Frontiers in public health 20150126

<h4>Introduction</h4>The incidence rate of end-stage renal disease (ESRD) is highest among African-American (AA) males. The reason for this disparity in ESRD for AA males remains unclear, but it is well established that diabetes is the leading risk factor. Prediabetes may also be a risk for kidney disease since prediabetics have increased risk for cardiovascular disease and often do not receive drug interventions unless their hemoglobin A1c (A1c) level is above 6%. Perhaps, AA males are at great ...[more]

PMID: 25674558

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Project description:BACKGROUND:Disparities in the prevalence of HIV persist in the southern United States, and young African American women have a disproportionate burden of HIV as compared with young women of other racial/ethnic backgrounds. As a result, engaging young African American women in the HIV care continuum through HIV testing is imperative. This study is designed to reach this key population at risk for HIV. The study seeks to test the efficacy of two formats of a gender-focused, evidence-based, HIV-risk reduction intervention-the Young Women's CoOp (YWC)-relative to HIV counseling and testing (HCT) among young African American women between the ages of 18 and 25 who use substances and have not recently been tested for HIV. METHODS:Using a seek-and-test framework, this three-arm cross-over randomized trial is being conducted in three county health departments in North Carolina. Each county is assigned to one of three study arms in each cycle: in-person (face-to-face) YWC, mobile Health (mHealth) YWC, or HCT. At study enrollment, participants complete a risk behavior survey via audio computer-assisted self-interview, and drug, alcohol, and pregnancy screening tests, and are then referred to HIV, gonorrhea, and chlamydia testing through their respective health departments. Participants in either of the YWC arms are asked to return approximately 1 week later to either begin the first of two in-person individual intervention sessions or to pick up the mHealth intervention preloaded on a tablet after a brief introduction to using the app. Participants in all arms are asked to return for a 6-month follow-up and 12-month follow-up, and repeat the survey and biological testing from baseline. DISCUSSION:The findings from this study will demonstrate which delivery format (mHealth or face-to-face) is efficacious in reducing substance use and sexual risk behaviors. If found to be efficacious, the intervention has potential for wider dissemination and reach. TRIAL REGISTRATION:ClinicalTrials.gov: NCT02965014 . Registered November 16, 2016.

Dataset Information

Gender differences in preclinical markers of kidney injury in a rural north Carolina african-american cohort.

Introduction

Methods

Results

Conclusion

Publications

Gender differences in preclinical markers of kidney injury in a rural north Carolina african-american cohort.

Similar Datasets

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