Dataset Information

The effect of bicarbonate administration via continuous venovenous hemofiltration on acid-base parameters in ventilated patients.

ABSTRACT:

Background

Acute kidney injury (AKI) and metabolic acidosis are common in the intensive care unit. The effect of bicarbonate administration on acid-base parameters is unclear in those receiving continuous venovenous hemofiltration (CVVH) and mechanical ventilatory support.

Methods

Metabolic and ventilatory parameters were prospectively examined in 19 ventilated subjects for up to 96 hours following CVVH initiation for AKI at an academic tertiary care center. Mixed linear regression modeling was performed to measure changes in pH, partial pressure of carbon dioxide (pCO2), serum bicarbonate, and base excess over time.

Results

During the 96-hour study period, pCO2 levels remained stable overall (initial pCO2 42.0±14.6 versus end-study pCO2 43.8±16.1?mmHg; P=0.13 for interaction with time), for those with initial pCO2?40?mmHg (31.3±5.7 versus 35.0±4.8; P=0.06) and for those with initial pCO2>40?mmHg (52.7±12.8 versus 53.4±19.2; P=0.57). pCO2 decreased during the immediate hours following CVVH initiation (42.0±14.6 versus 37.3±12.6?mmHg), though this change was nonsignificant (P=0.052).

Conclusions

We did not detect a significant increase in pCO2 in response to the administration of bicarbonate via CVVH in a ventilated population. Additional studies of larger populations are needed to confirm this finding.

SUBMITTER: Allegretti AS

PROVIDER: S-EPMC4306401 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

The effect of bicarbonate administration via continuous venovenous hemofiltration on acid-base parameters in ventilated patients.

Allegretti Andrew S AS Flythe Jennifer E JE Benda Vinod V Robinson Emily S ES Charytan David M DM

BioMed research international 20150108

<h4>Background</h4>Acute kidney injury (AKI) and metabolic acidosis are common in the intensive care unit. The effect of bicarbonate administration on acid-base parameters is unclear in those receiving continuous venovenous hemofiltration (CVVH) and mechanical ventilatory support.<h4>Methods</h4>Metabolic and ventilatory parameters were prospectively examined in 19 ventilated subjects for up to 96 hours following CVVH initiation for AKI at an academic tertiary care center. Mixed linear regressio ...[more]

PMID: 25648653

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Dataset Information

The effect of bicarbonate administration via continuous venovenous hemofiltration on acid-base parameters in ventilated patients.

Background

Methods

Results

Conclusions

Publications

The effect of bicarbonate administration via continuous venovenous hemofiltration on acid-base parameters in ventilated patients.

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