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Optical coherence tomography identifies lower labial salivary gland surface density in cystic fibrosis.


ABSTRACT: The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The median LSGs' surface densities in CF patients, and in the control group were 4.32 glands/cm2 and 6.58 glands/cm2, respectively (p = 0.006; Mann-Whitney U test). A lower LSG surface density is a previously unrecognized CF-related pathology of the alimentary tract.

SUBMITTER: Nowak JK 

PROVIDER: S-EPMC4306485 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Optical coherence tomography identifies lower labial salivary gland surface density in cystic fibrosis.

Nowak Jan K JK   Grulkowski Ireneusz I   Karnowski Karol K   Wojtkowski Maciej M   Walkowiak Jaroslaw J  

PloS one 20150126 1


The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The median LSGs' surface densities in CF  ...[more]

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