Ontology highlight
ABSTRACT:
SUBMITTER: Saya L
PROVIDER: S-EPMC4306596 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Saya Lucía L Fernández Israel I López Fernando F Mascareñas José L JL
Organic letters 20140918 19
A highly diastereo- and chemoselective intramolecular nickel-catalyzed cycloaddition of alkene- and alkyne-tethered alkynylidenecyclopropanes is reported. The method constitutes the first fully intramolecular [3 + 2 + 2] alkylidenecyclopropropane cycloaddition occurring via a proximal cleavage of the cyclopropane and makes it possible to build relevant 6,7,5-tricyclic frameworks in a single-pot reaction. Importantly, the reaction outcome is highly dependent on the characteristics of the nickel l ...[more]