Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Eauclaire MF
PROVIDER: S-EPMC4306711 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Martin-Eauclaire Marie-France MF Ferracci Géraldine G Bosmans Frank F Bougis Pierre E PE
The Journal of general physiology 20150201 2
Animal toxins that inhibit voltage-gated sodium (Na(v)) channel fast inactivation can do so through an interaction with the S3b-S4 helix-turn-helix region, or paddle motif, located in the domain IV voltage sensor. Here, we used surface plasmon resonance (SPR), an optical approach that uses polarized light to measure the refractive index near a sensor surface to which a molecule of interest is attached, to analyze interactions between the isolated domain IV paddle and Na(v) channel-selective α-sc ...[more]