New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.
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ABSTRACT:
SUBMITTER: Lacret R
PROVIDER: S-EPMC4306928 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
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New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.
Lacret Rodney R Oves-Costales Daniel D Gómez Cristina C Díaz Caridad C de la Cruz Mercedes M Pérez-Victoria Ignacio I Vicente Francisca F Genilloud Olga O Reyes Fernando F
Marine drugs 20141229 1
A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compo ...[more]
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