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MiR-124 rs531564 polymorphism influences genetic susceptibility to cervical cancer.

ABSTRACT: Cervical cancer is the fourth most common cancer among women worldwide. It most frequently results from human papillomavirus (HPV) infection; however, recent evidence suggests that there may be underlying genetic factors, specifically in regions encoding microRNAs, dictating susceptibility to cervical cancer. This study investigated the relationship between the miR-124 rs531564 gene polymorphism and genetic susceptibility to cervical cancer in Chinese Han women. From January 2011 to July 2013, 158 Chinese Han cervical cancer patients and 260 healthy Chinese Han females were recruited to provide blood samples. The miR-124 rs531564 (C > G) polymorphism genotype was determined by polymerase chain reaction-based ligase detection reaction (PCR-LDR), and multivariate logistic regression analysis was used to deduce the relationship between the miR-124 rs531564 variant and cancer diagnosis. As expected, the incidence of HPV infection in cervical cancer patients was significantly higher than controls (P < 0.001). Logistic regression analysis showed that a CG genotype was associated with reduced risk of cervical cancer compared to the wildtype CC genotype (OR = 0.46, 95% CI: 0.19-0.92); the findings were similar when the variant genotypes were combined (CG + GG; OR = 0.42, 95% CI: 0.17-0.86). The G allele was associated with reduced risk of cervical cancer (OR = 0.45, 95% CI: 0.14-0.89) particularly among women over age 40 (OR = 0.31, 95% CI: 0.12-0.84), as well as reduced risk of HPV infection (OR = 0.59, 95% CI: 0.28-0.93). These results further support a role for genetic susceptibility in miR-124 rs531564 in determining the risk of cervical cancer in Chinese Han women.

SUBMITTER: Wu H

PROVIDER: S-EPMC4307565 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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miR-124 rs531564 polymorphism influences genetic susceptibility to cervical cancer.

Wu Henghui H Zhang Juxin J

International journal of clinical and experimental medicine 20141215 12

Cervical cancer is the fourth most common cancer among women worldwide. It most frequently results from human papillomavirus (HPV) infection; however, recent evidence suggests that there may be underlying genetic factors, specifically in regions encoding microRNAs, dictating susceptibility to cervical cancer. This study investigated the relationship between the miR-124 rs531564 gene polymorphism and genetic susceptibility to cervical cancer in Chinese Han women. From January 2011 to July 2013, 1 ...[more]

PMID: 25664118

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Project description:To investigate the association between the susceptibility to cervical cancer and the single nucleotide polymorphisms of 5 tumor necrosis factor-α promoter genes (rs361525, rs1800629, rs1800750, rs1799964, and rs673) in Chinese women. A total of 946 peripheral blood samples were collected from women of Han Ethnicity in Shandong province. Of them, 452 were diagnosed with cervical squamous cell carcinomas. The study also included a control group of 494 healthy women. The targeted single nucleotide polymorphisms were analyzed by TaqMan probe method. (1) The rate of high-risk subtype human papillomavirus infection in exfoliated cervical epithelial cells was significantly higher in patients with cervical cancer than the control group (91.4% vs 10.3%, P < .01). The rate of human papillomavirus infection was lower in patients with carcinoma in situ than those with invasive carcinoma (77.9% vs 95.4%, P < .01). (2) There was a significant difference for rs361525 genotype (CC/CT/TT) between the control, carcinoma in situ, and invasive carcinoma groups ( P < .001). Both rs1800629 and rs1799964 genotypes (both GG/GA/AA) were also different between these groups ( P < .001 and P < .001). (3) The allele frequencies of rs361525, rs1800629, and rs1799964 were significantly correlated with the diagnosis of cervical cancer. The frequency of T allele in rs361525 was significantly higher for cervical cancer group (10.8%) than control group (3.8%; odds ratio = 3.04, 95% confidence interval = 1.76-5.25, P < .01). The frequency of A allele in rs1800629 was significantly higher for cervical cancer (29.9%) than control group (14.2%; odds ratio = 2.58, 95% confidence interval = 1.87-3.56, P < .01). The frequency of A allele in rs1799964 was also higher for cervical cancer group (38.3%) than control group (16.4%; odds ratio = 1.43, 95% confidence interval = 1.07-1.91, P < .05). The rs361525, rs1800629, and rs17999645 were significantly correlated with the diagnosis of cervical cancer.

Dataset Information

MiR-124 rs531564 polymorphism influences genetic susceptibility to cervical cancer.

Publications

miR-124 rs531564 polymorphism influences genetic susceptibility to cervical cancer.

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