Ontology highlight
ABSTRACT:
SUBMITTER: Marquis JF
PROVIDER: S-EPMC4307599 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Marquis Jean-François JF LaCourse Ronald R Ryan Lynn L North Robert J RJ Gros Philippe P
Journal of immunology (Baltimore, Md. : 1950) 20090301 5
The interferon regulatory factor (IRF) family member IRF-8 participates in IFN-gamma-dependent transcriptional activation of genes containing in their promoter regions IFN-stimulated response element or IFN-gamma activation site elements. To test the role of IRF-8 in host defenses against tuberculosis, BXH-2 mice, which bear a defective IRF-8(R294C) allele, were challenged with low doses of virulent Mycobacterium tuberculosis via the i.v. and aerosol routes. BXH-2 mice were found to be extremely ...[more]