Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4308685 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Wang Jiguang J Khiabanian Hossein H Rossi Davide D Fabbri Giulia G Gattei Valter V Forconi Francesco F Laurenti Luca L Marasca Roberto R Del Poeta Giovanni G Foà Robin R Pasqualucci Laura L Gaidano Gianluca G Rabadan Raul R
eLife 20141211
Cancer is a clonal evolutionary process, caused by successive accumulation of genetic alterations providing milestones of tumor initiation, progression, dissemination, and/or resistance to certain therapeutic regimes. To unravel these milestones we propose a framework, tumor evolutionary directed graphs (TEDG), which is able to characterize the history of genetic alterations by integrating longitudinal and cross-sectional genomic data. We applied TEDG to a chronic lymphocytic leukemia (CLL) coho ...[more]