Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression.
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ABSTRACT:
SUBMITTER: Pervouchine DD
PROVIDER: S-EPMC4308717 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression.
Pervouchine Dmitri D DD Djebali Sarah S Breschi Alessandra A Davis Carrie A CA Barja Pablo Prieto PP Dobin Alex A Tanzer Andrea A Lagarde Julien J Zaleski Chris C See Lei-Hoon LH Fastuca Meagan M Drenkow Jorg J Wang Huaien H Bussotti Giovanni G Pei Baikang B Balasubramanian Suganthi S Monlong Jean J Harmanci Arif A Gerstein Mark M Beer Michael A MA Notredame Cedric C Guigó Roderic R Gingeras Thomas R TR
Nature communications 20150113
Mice have been a long-standing model for human biology and disease. Here we characterize, by RNA sequencing, the transcriptional profiles of a large and heterogeneous collection of mouse tissues, augmenting the mouse transcriptome with thousands of novel transcript candidates. Comparison with transcriptome profiles in human cell lines reveals substantial conservation of transcriptional programmes, and uncovers a distinct class of genes with levels of expression that have been constrained early i ...[more]
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