Ontology highlight
ABSTRACT:
SUBMITTER: Fazzio TG
PROVIDER: S-EPMC4308735 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Cell 20080701 1
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We identified 68 proteins that exhibit diverse phenotypes upon knockdown (KD), including seven subunits of the Tip60-p400 complex. Phenotypic analyses revealed that Tip60-p400 is necessary to maintain c ...[more]