Dataset Information

Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.

ABSTRACT:

Background and purpose

Studies investigating the association between 25-hydroxyvitamin D [25(OH)D] and cognition in the very old (85+) are lacking.

Methods

Cross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by the Standardized Mini-Mental State Examination) and attention-specific (measured by the attention battery of the Cognitive Drug Research test) cognitive performance in relation to season-specific 25(OH)D quartiles.

Results

Those in the lowest and highest season-specific 25(OH)D quartiles had an increased risk of impaired prevalent (1.66, 95% confidence interval 1.06-2.60, P = 0.03; 1.62, 95% confidence interval 1.02-2.59, P = 0.04, respectively) but not incident global cognitive functioning or decline in functioning compared with those in the middle quartiles adjusted for sociodemographic, health and lifestyle confounders. Random effects models showed that participants belonging to the lowest and highest 25(OH)D quartiles, compared with those in the middle quartiles, had overall slower (log-transformed) attention reaction times for Choice Reaction Time (lowest, ? = 0.023, P = 0.01; highest, ? = 0.021, P = 0.02), Digit Vigilance Task (lowest, ? = 0.009, P = 0.05; highest, ? = 0.01, P = 0.02) and Power of Attention (lowest, ? = 0.017, P = 0.02; highest, ? = 0.022, P = 0.002) and greater Reaction Time Variability (lowest, ? = 0.021, P = 0.02; highest, ? = 0.02, P = 0.03). The increased risk of worse global cognition and attention amongst those in the highest quartile was not observed in non-users of vitamin D supplements/medication.

Conclusion

Low and high season-specific 25(OH)D quartiles were associated with prevalent cognitive impairment and poorer overall performance in attention-specific tasks over 3 years in the very old, but not with global cognitive decline or incident impairment.

SUBMITTER: Granic A

PROVIDER: S-EPMC4310141 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Publications

Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.

Granic A A Hill T R TR Kirkwood T B L TB Davies K K Collerton J J Martin-Ruiz C C von Zglinicki T T Saxby B K BK Wesnes K A KA Collerton D D Mathers J C JC Jagger C C

European journal of neurology 20140813 1

<h4>Background and purpose</h4>Studies investigating the association between 25-hydroxyvitamin D [25(OH)D] and cognition in the very old (85+) are lacking.<h4>Methods</h4>Cross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by the Standardized Mini-Mental State Examination) and attention-specific (measured by the attention battery of the Cognitive Drug Research test) cognitive performance in ...[more]

PMID: 25117780

Similar Datasets

Project description:ObjectivesAlthough the biological rationale for the association between folate, vitamin B12, and homocysteine with cognitive function seems plausible, conflicting results have been reported. This study aimed to determine the associations between 1-carbon (1-C) metabolism biomarkers (folate, vitamin B12, and homocysteine), and cognitive impairment at baseline and the rate of cognitive decline over 5 years in the very old.DesignThe Newcastle 85+ Study was a prospective longitudinal study of people 85 years old and followed over 5 years in Northeast England.SettingCommunity-dwelling and institutionalized.ParticipantsThe analytical sample included 765 very old participants with 1-C metabolism biomarkers and cognitive measures.MeasurementsGlobal cognition was measured by the Standardized Mini-Mental State Examination (SMMSE) at baseline, and at 3 and 5 years of follow-up and, attention-specific cognition with the Cognitive Drug Research (CDR) System at baseline, and at 1.5 and 3.0 years of follow-up. Baseline red blood cell folate (RBC folate), plasma vitamin B12, and total homocysteine (tHcy) concentrations were determined by immunoassay. Linear mixed models were used to estimate the associations between quartiles of 1-C metabolism biomarkers and cognition over 3 (CDR) and 5 years (SMMSE).ResultsCompared with participants in the lowest quartile of RBC folate concentrations (<612 nmol/L), those in the highest quartile of RBC folate concentrations (>1280 nmol/L) had 1 more point on the SMMSE at baseline (β = +1.02, SE = 0.43, P = .02). Those in quartile 4 of tHcy (>21.4 μmol/L) had 1 point less in the SMMSE at baseline than those in the lowest quartile (<13.5 μmol/L) (β = -1.05, SE = 0.46, P = .02). Plasma vitamin B12 was not predictive of global or attention-specific cognition at baseline and at follow-up. None of the 1-C metabolism biomarkers except tHcy was associated with the rate of decline in attention scores over 3 years.ConclusionRBC folate and tHcy, but not plasma vitamin B12, were associated with better global cognition in the very old at baseline but were not predictive of rate of decline over 5 years.

Dataset Information

Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.

Background and purpose

Methods

Results

Conclusion

Publications

Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.

Similar Datasets

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