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Combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery.


ABSTRACT: Increases in serum creatinine (?SCr) from baseline signify acute kidney injury (AKI) but offer little granular information regarding its characteristics. The 10th Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) suggested that combining AKI biomarkers would provide better precision for AKI course prognostication.This study investigated the value of combining a functional damage biomarker (plasma cystatin C [pCysC]) with a tubular damage biomarker (urine neutrophil gelatinase-associated lipocalin [uNGAL]), forming a composite biomarker for prediction of discrete characteristics of AKI.Data from 345 children after cardiopulmonary bypass (CPB) were analyzed. Severe AKI was defined as Kidney Disease Global Outcomes Initiative stages 2 to 3 (?100% ?SCr) within 7 days of CPB. Persistent AKI lasted >2 days. SCr in reversible AKI returned to baseline ?48 h after CPB. The composite of uNGAL (>200 ng/mg urine Cr = positive [+]) and pCysC (>0.8 mg/l = positive [+]), uNGAL+/pCysC+, measured 2 h after CPB initiation, was compared to ?SCr increases of ?50% for correlation with AKI characteristics by using predictive probabilities, likelihood ratios (LR), and area under the curve receiver operating curve (AUC-ROC) values [Corrected].Severe AKI occurred in 18% of patients. The composite uNGAL+/pCysC+ demonstrated a greater likelihood than ?SCr for severe AKI (+LR: 34.2 [13.0:94.0] vs. 3.8 [1.9:7.2]) and persistent AKI (+LR: 15.6 [8.8:27.5] versus 4.5 [2.3:8.8]). In AKI patients, the uNGAL-/pCysC+ composite was superior to ?SCr for prediction of transient AKI. Biomarker composites carried greater probability for specific outcomes than ?SCr strata.Composites of functional and tubular damage biomarkers are superior to ?SCr for predicting discrete characteristics of AKI.

SUBMITTER: Basu RK 

PROVIDER: S-EPMC4310455 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery.

Basu Rajit K RK   Wong Hector R HR   Krawczeski Catherine D CD   Wheeler Derek S DS   Manning Peter B PB   Chawla Lakhmir S LS   Devarajan Prasad P   Goldstein Stuart L SL  

Journal of the American College of Cardiology 20141201 25


<h4>Background</h4>Increases in serum creatinine (ΔSCr) from baseline signify acute kidney injury (AKI) but offer little granular information regarding its characteristics. The 10th Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) suggested that combining AKI biomarkers would provide better precision for AKI course prognostication.<h4>Objectives</h4>This study investigated the value of combining a functional damage biomarker (plasma cystatin C [pCysC]) with a tubular damage b  ...[more]

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