Ontology highlight
ABSTRACT:
SUBMITTER: De Majumdar S
PROVIDER: S-EPMC4310594 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
De Majumdar Shyamasree S Yu Jing J Fookes Maria M McAteer Sean P SP Llobet Enrique E Finn Sarah S Spence Shaun S Monahan Avril A Monaghan Avril A Kissenpfennig Adrien A Ingram Rebecca J RJ Bengoechea José J Gally David L DL Fanning Séamus S Elborn Joseph S JS Schneiders Thamarai T
PLoS pathogens 20150129 1
Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism during infection. In this work, we demonstrate that RamA is a global transcriptional regulator that significantly perturbs the transcriptional landscape of K. pneumoniae, resulting ...[more]