A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors.
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ABSTRACT:
SUBMITTER: Ortega DR
PROVIDER: S-EPMC4310728 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors.
Ortega Davi R DR Yang Chen C Ames Peter P Baudry Jerome J Parkinson John S JS Zhulin Igor B IB
Nature communications 20130101
Bacterial chemoreceptors are widely used as a model system for elucidating the molecular mechanisms of transmembrane signalling and have provided a detailed understanding of how ligand binding by the receptor modulates the activity of its associated kinase CheA. However, the mechanisms by which conformational signals move between signalling elements within a receptor dimer and how they control kinase activity remain unknown. Here, using long molecular dynamics simulations, we show that the kinas ...[more]
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