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Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and ?-cyclodextrin polymers.

ABSTRACT: Novel (S)-camptothecin-dextran polymers were obtained by "click" grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with ?-cyclodextrin and ?-cyclodextrin polymers were measured by isothermal titration calorimetry and fluorescence spectroscopy, showing no binding with ?-cyclodextrin but high binding with ?-cyclodextrin polymers. In aqueous solution nanoparticles were formed from association between the (S)-camptothecin-dextran polymers and the ?-cyclodextrin polymers.

SUBMITTER: Nielsen TT

PROVIDER: S-EPMC4311650 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers.

Nielsen Thorbjørn Terndrup TT Amiel Catherine C Duroux Laurent L Larsen Kim Lambertsen KL Städe Lars Wagner LW Wimmer Reinhard R Wintgens Véronique V

Beilstein journal of organic chemistry 20150121

Novel (S)-camptothecin-dextran polymers were obtained by "click" grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with β-cyclodextrin and β-cyclodextrin polymers were measured by isothermal titration calorimetry and fluorescence spectroscopy, showing no binding with β-cyclodextrin but high binding with β-cyclodextrin ...[more]

PMID: 25670998

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