Ontology highlight
ABSTRACT:
SUBMITTER: Eikenes AH
PROVIDER: S-EPMC4312039 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Eikenes Åsmund H ÅH Malerød Lene L Christensen Anette Lie AL Steen Chloé B CB Mathieu Juliette J Nezis Ioannis P IP Liestøl Knut K Huynh Jean-René JR Stenmark Harald H Haglund Kaisa K
PLoS genetics 20150130 1
Abscission is the final step of cytokinesis that involves the cleavage of the intercellular bridge connecting the two daughter cells. Recent studies have given novel insight into the spatiotemporal regulation and molecular mechanisms controlling abscission in cultured yeast and human cells. The mechanisms of abscission in living metazoan tissues are however not well understood. Here we show that ALIX and the ESCRT-III component Shrub are required for completion of abscission during Drosophila fe ...[more]