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BRAF inhibitors: experience in thyroid cancer and general review of toxicity.

ABSTRACT: The US Food and Drug Administration-approved BRAF inhibitors, vemurafenib and dabrafenib, have demonstrated superior efficacy in patients with BRAF-mutant melanomas but have limited efficacy in BRAF-mutant colorectal cancer. Little is known at this time regarding BRAF inhibitors in thyroid cancer. Initial reports in patients with progressive, radioactive iodine-refractory BRAF-mutant papillary thyroid cancer suggest response rates of approximately 30-40%. In this review, we discuss BRAF inhibitors in the context of thyroid cancer, the toxicities associated with BRAF inhibitors, and the suggested management of those toxicities. The management of vemurafenib and dabrafenib toxicities is applicable across all tumor types and may serve as a practical guide to their use.

SUBMITTER: Cabanillas ME

PROVIDER: S-EPMC4312215 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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BRAF inhibitors: experience in thyroid cancer and general review of toxicity.

Cabanillas M E ME Patel A A Danysh B P BP Dadu R R Kopetz S S Falchook G G

Hormones & cancer 20141203 1

The US Food and Drug Administration-approved BRAF inhibitors, vemurafenib and dabrafenib, have demonstrated superior efficacy in patients with BRAF-mutant melanomas but have limited efficacy in BRAF-mutant colorectal cancer. Little is known at this time regarding BRAF inhibitors in thyroid cancer. Initial reports in patients with progressive, radioactive iodine-refractory BRAF-mutant papillary thyroid cancer suggest response rates of approximately 30-40%. In this review, we discuss BRAF inhibito ...[more]

PMID: 25467940

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