Ontology highlight
ABSTRACT:
SUBMITTER: Nieh EH
PROVIDER: S-EPMC4312417 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Nieh Edward H EH Matthews Gillian A GA Allsop Stephen A SA Presbrey Kara N KN Leppla Christopher A CA Wichmann Romy R Neve Rachael R Wildes Craig P CP Tye Kay M KM
Cell 20150101 3
The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processing, but the computations within the LH-VTA loop that give rise to specific aspects of behavior have been difficult to isolate. We show that LH-VTA neurons encode the learned action of seeking a reward, independent of reward availability. In contrast, LH neurons downstream of VTA encode reward-predictive cues and unexpected reward omission. We show that inhibiting the LH-VTA pathway redu ...[more]