Ontology highlight
ABSTRACT:
SUBMITTER: Chen SL
PROVIDER: S-EPMC4313085 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chen Shiou-Lan SL Lee Sheng-Yu SY Chang Yun-Hsuan YH Wang Tzu-Yun TY Chen Shih-Heng SH Chu Chun-Hsien CH Chen Po See PS Yang Yen Kuang YK Hong Jau-Shyong JS Lu Ru-Band RB
Scientific reports 20150202
BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients. The pretreatment expression levels of plasma BDNF and the BDNF Val66Met SNP in 172 heroin-dependent patients and 102 healthy controls were ...[more]