Ontology highlight
ABSTRACT:
SUBMITTER: Jin N
PROVIDER: S-EPMC4313118 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Jin Nana N Yin Xiaomin X Yu Dian D Cao Maohong M Gong Cheng-Xin CX Iqbal Khalid K Ding Fei F Gu Xiaosong X Liu Fei F
Scientific reports 20150202
Abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. Glycogen synthase kinase 3β (GSK-3β) is a primary tau kinase that is most implicated in tau pathology in AD. However, the exact molecular nature of GSK-3β involved in AD is unclear. In the present study, we found that GSK-3β was truncated at C-terminus and correlated with over-activation of calpain I in AD brain. Truncation of GSK-3β was positively correlated with t ...[more]