Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients.
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ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC4313413 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
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Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients.
Wang Ting T Green Linden A LA Gupta Samir K SK Amet Tohti T Byrd Daniel J DJ Yu Qigui Q Twigg Homer L HL Clauss Matthias M
AIDS research and human retroviruses 20140904 2
We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART. ...[more]
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