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Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients.


ABSTRACT: We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.

SUBMITTER: Wang T 

PROVIDER: S-EPMC4313413 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients.

Wang Ting T   Green Linden A LA   Gupta Samir K SK   Amet Tohti T   Byrd Daniel J DJ   Yu Qigui Q   Twigg Homer L HL   Clauss Matthias M  

AIDS research and human retroviruses 20140904 2


We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART. ...[more]

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