Dataset Information

Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.

ABSTRACT: To investigate the association of three polymorphisms in the Interleukin-27 (IL-27) gene with CD risk in Chinese population.This case-control study involved 312 CD patients and 479 age- and sex-matched healthy controls. Genotyping was performed using PCR-LDR method. Data were analyzed using Haplo. Stats program.There were significant differences between patients and controls in allele distributions of rs153109 (Pallele = 0.036). The risk for CD associated with the rs153109-G mutant allele was increased by 26% (95% CI [confidence interval]: 1.02-1.56; P = 0.03) under the additive model and by 45% (95% CI: 1.07-1.97; P = 0.02) under the dominant model. In haplotype analysis, haplotype T-T-G (in order of rs17855750, rs181206 and rs153109) increased the odds of CD by 37% (95% CI: 1.04-1.81; P = 0.028).In conclusion, genetic defects in IL-27 gene showed remarkable associations with CD in Chinese.

SUBMITTER: Wang Z

PROVIDER: S-EPMC4313976 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.

Wang Zhengting Z Wang Lei L Fan Rong R Zhou Jie J Zhong Jie J

International journal of clinical and experimental pathology 20141201 12

<h4>Objective</h4>To investigate the association of three polymorphisms in the Interleukin-27 (IL-27) gene with CD risk in Chinese population.<h4>Methods</h4>This case-control study involved 312 CD patients and 479 age- and sex-matched healthy controls. Genotyping was performed using PCR-LDR method. Data were analyzed using Haplo. Stats program.<h4>Results</h4>There were significant differences between patients and controls in allele distributions of rs153109 (Pallele = 0.036). The risk for CD a ...[more]

PMID: 25674271

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Project description:BackgroundThe identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China. However, Chinese Han people from different geographic areas may have different genetic backgrounds. This study aims to assess the genetic associations of the eight SNPs mentioned above with three cancers risk in a Han population from northwest China.MethodsA total of 186 cancer-free controls and 436 cases with non-small cell lung cancer (NSCLC) (159 cases), non-cardia GC (167 cases) or EC (110 cases) were enrolled in this study. Chi-square test and polytomous logistic regression analyses were used to estimate the association between eight cancer-related SNPs and three cancers in a Han Chinese population from northwest China. The logistic regression results were adjusted for confounding factors and Benjamini and Hochberg False Discovery Rate (FDR) method was used to adjust the multiple hypothesis tests. Association analyses by cigarette smoking or alcohol drinking status were analyzed by crossover analyses.ResultsOne of the eight SNPs, rs17728461 was associated with NSCLC susceptibility (in a heterozygous model, OR = 0.44, 95% CI = 0.27-0.72, p = 0.001). Two SNPs, rs753955 and rs13042395, were associated with the risk of non-cardia GC in different genetic models (p < 0.05). No SNPs were associated with EC. The crossover analyses showed that the rs13042395 CT genotype, combined with cigarette smoking or alcohol drinking, could further increase the risk for non-cardia GC (p < 0.05).ConclusionsThese results indicated that rs17728461 may be specifically associated with the risk of NSCLC. rs753955 and rs13042395 were specifically associated with susceptibility to non-cardia GC in Ningxia Han Chinese. Susceptibility-associated polymorphisms in the northwestern Han Chinese were not very consistent with those in the northern Han Chinese or southern Han Chinese. The validation of these findings with a functional evaluation and a larger population is still required.

Dataset Information

Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.

Publications

Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.

Similar Datasets

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