Data-driven asthma endotypes defined from blood biomarker and gene expression data.
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ABSTRACT:
SUBMITTER: George BJ
PROVIDER: S-EPMC4314082 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Data-driven asthma endotypes defined from blood biomarker and gene expression data.
George Barbara Jane BJ Reif David M DM Gallagher Jane E JE Williams-DeVane ClarLynda R CR Heidenfelder Brooke L BL Hudgens Edward E EE Jones Wendell W Neas Lucas L Hubal Elaine A Cohen EA Edwards Stephen W SW
PloS one 20150202 2
The diagnosis and treatment of childhood asthma is complicated by its mechanistically distinct subtypes (endotypes) driven by genetic susceptibility and modulating environmental factors. Clinical biomarkers and blood gene expression were collected from a stratified, cross-sectional study of asthmatic and non-asthmatic children from Detroit, MI. This study describes four distinct asthma endotypes identified via a purely data-driven method. Our method was specifically designed to integrate blood g ...[more]
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