Ontology highlight
ABSTRACT:
SUBMITTER: Pereira RM
PROVIDER: S-EPMC4314221 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Pereira Renata M RM Martinez Gustavo J GJ Engel Isaac I Cruz-Guilloty Fernando F Barboza Bianca A BA Tsagaratou Ageliki A Tsagaratou Ageliki A Lio Chan-Wang J CW Berg Leslie J LJ Lee Youngsook Y Kronenberg Mitchell M Bandukwala Hozefa S HS Rao Anjana A
Nature communications 20140808
Jarid2 is a reported component of three lysine methyltransferase complexes, polycomb repressive complex 2 (PRC2) that methylates histone 3 lysine 27 (H3K27), and GLP-G9a and SETDB1 complexes that methylate H3K9. Here we show that Jarid2 is upregulated upon TCR stimulation and during positive selection in the thymus. Mice lacking Jarid2 in T cells display an increase in the frequency of IL-4-producing promyelocytic leukemia zinc finger (PLZF)(hi) immature invariant natural killer T (iNKT) cells a ...[more]