Unknown

Dataset Information

0

Jarid2 is induced by TCR signalling and controls iNKT cell maturation.


ABSTRACT: Jarid2 is a reported component of three lysine methyltransferase complexes, polycomb repressive complex 2 (PRC2) that methylates histone 3 lysine 27 (H3K27), and GLP-G9a and SETDB1 complexes that methylate H3K9. Here we show that Jarid2 is upregulated upon TCR stimulation and during positive selection in the thymus. Mice lacking Jarid2 in T cells display an increase in the frequency of IL-4-producing promyelocytic leukemia zinc finger (PLZF)(hi) immature invariant natural killer T (iNKT) cells and innate-like CD8(+) cells; Itk-deficient mice, which have a similar increase of innate-like CD8(+) cells, show blunted upregulation of Jarid2 during positive selection. Jarid2 binds to the Zbtb16 locus, which encodes PLZF, and thymocytes lacking Jarid2 show increased PLZF and decreased H3K9me3 levels. Jarid2-deficient iNKT cells perturb Th17 differentiation, leading to reduced Th17-driven autoimmune pathology. Our results establish Jarid2 as a novel player in iNKT cell maturation that regulates PLZF expression by modulating H3K9 methylation.

SUBMITTER: Pereira RM 

PROVIDER: S-EPMC4314221 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications


Jarid2 is a reported component of three lysine methyltransferase complexes, polycomb repressive complex 2 (PRC2) that methylates histone 3 lysine 27 (H3K27), and GLP-G9a and SETDB1 complexes that methylate H3K9. Here we show that Jarid2 is upregulated upon TCR stimulation and during positive selection in the thymus. Mice lacking Jarid2 in T cells display an increase in the frequency of IL-4-producing promyelocytic leukemia zinc finger (PLZF)(hi) immature invariant natural killer T (iNKT) cells a  ...[more]

Similar Datasets

| S-EPMC6037704 | biostudies-literature
| S-EPMC8655039 | biostudies-literature
2018-05-18 | GSE111427 | GEO
2018-05-17 | GSE110327 | GEO
| S-EPMC7308083 | biostudies-literature
| S-EPMC10282035 | biostudies-literature
| S-EPMC10942104 | biostudies-literature
| S-EPMC6804728 | biostudies-literature
| S-EPMC3879349 | biostudies-literature
| S-EPMC6959360 | biostudies-literature