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A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania.

ABSTRACT: BACKGROUND:Aflatoxin and fumonisin are toxic food contaminants. Knowledge about effects of their exposure and coexposure on child growth is inadequate. OBJECTIVE:We investigated the association between child growth and aflatoxin and fumonisin exposure in Tanzania. METHODS:A total of 166 children were recruited at 6-14 months of age and studied at recruitment, and at the 6th and 12th month following recruitment. Blood and urine samples were collected and analyzed for plasma aflatoxin-albumin adducts (AF-alb) using ELISA, and urinary fumonisin B1 (UFB1) using liquid chromatography-mass spectrometry, respectively. Anthropometric measurements were taken, and growth index z-scores were computed. RESULTS:AF-alb geometric mean concentrations (95% CIs) were 4.7 (3.9, 5.6), 12.9 (9.9, 16.7), and 23.5 (19.9, 27.7) pg/mg albumin at recruitment, 6 months, and 12 months from recruitment, respectively. At these respective sampling times, geometric mean UFB1 concentrations (95% CI) were 313.9 (257.4, 382.9), 167.3 (135.4, 206.7), and 569.5 (464.5, 698.2) pg/mL urine, and the prevalence of stunted children was 44%, 55%, and 56%, respectively. UFB1 concentrations at recruitment were negatively associated with length-for-age z-scores (LAZ) at 6 months (p = 0.016) and at 12 months from recruitment (p = 0.014). The mean UFB1 of the three sampling times (at recruitment and at 6 and 12 months from recruitment) in each child was negatively associated with LAZ (p < 0.001) and length velocity (p = 0.004) at 12 months from recruitment. The negative association between AF-alb and child growth did not reach statistical significance. CONCLUSIONS:Exposure to fumonisin alone or coexposure with aflatoxins may contribute to child growth impairment.

SUBMITTER: Shirima CP

PROVIDER: S-EPMC4314247 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania.

Shirima Candida P CP Kimanya Martin E ME Routledge Michael N MN Srey Chou C Kinabo Joyce L JL Humpf Hans-Ulrich HU Wild Christopher P CP Tu Yu-Kang YK Gong Yun Yun YY

Environmental health perspectives 20141017 2

<h4>Background</h4>Aflatoxin and fumonisin are toxic food contaminants. Knowledge about effects of their exposure and coexposure on child growth is inadequate.<h4>Objective</h4>We investigated the association between child growth and aflatoxin and fumonisin exposure in Tanzania.<h4>Methods</h4>A total of 166 children were recruited at 6-14 months of age and studied at recruitment, and at the 6th and 12th month following recruitment. Blood and urine samples were collected and analyzed for plasma ...[more]

PMID: 25325363

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Dataset Information

A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania.

Publications

A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania.

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