Microbial evolution. Global epistasis makes adaptation predictable despite sequence-level stochasticity.
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ABSTRACT:
SUBMITTER: Kryazhimskiy S
PROVIDER: S-EPMC4314286 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Microbial evolution. Global epistasis makes adaptation predictable despite sequence-level stochasticity.
Kryazhimskiy Sergey S Rice Daniel P DP Jerison Elizabeth R ER Desai Michael M MM
Science (New York, N.Y.) 20140601 6191
Epistatic interactions between mutations can make evolutionary trajectories contingent on the chance occurrence of initial mutations. We used experimental evolution in Saccharomyces cerevisiae to quantify this contingency, finding differences in adaptability among 64 closely related genotypes. Despite these differences, sequencing of 104 evolved clones showed that initial genotype did not constrain future mutational trajectories. Instead, reconstructed combinations of mutations revealed a patter ...[more]
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