MiR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells.
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ABSTRACT:
SUBMITTER: Ohira T
PROVIDER: S-EPMC4314654 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells.
Ohira Takahito T Naohiro Sunamura S Nakayama Yuji Y Osaki Mitsuhiko M Okada Futoshi F Oshimura Mitsuo M Kugoh Hiroyuki H
Scientific reports 20150203
Human telomerase reverse transcriptase (hTERT) plays a crucial role in cancer development. We previously identified paired-like homeodomain1 (PITX1) as an hTERT suppressor gene. However, the underlying mechanisms that are involved in the regulation of PITX1 remain unknown. Here, we report that the microRNA-19b (miR-19b) regulates hTERT expression and cell proliferation through inhibition of PITX1. Compared with normal melanocyte cells, miR-19b expression was higher in most melanoma cells and was ...[more]
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