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HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase.

ABSTRACT: Dysregulation of cell surface proteolysis has been strongly implicated in tumorigenicity and metastasis. In this study, we delineated the role of hepatocyte growth factor activator inhibitor-2 (HAI-2) in prostate cancer (PCa) cell migration, invasion, tumorigenicity and metastasis using a human PCa progression model (103E, N1, and N2 cells) and xenograft models. N1 and N2 cells were established through serial intraprostatic propagation of 103E human PCa cells and isolation of the metastatic cells from nearby lymph nodes. The invasion capability of these cells was revealed to gradually increase throughout the serial isolations (103E

SUBMITTER: Tsai CH

PROVIDER: S-EPMC4314694 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase.

Tsai C-H CH Teng C-H CH Tu Y-T YT Cheng T-S TS Wu S-R SR Ko C-J CJ Shyu H-Y HY Lan S-W SW Huang H-P HP Tzeng S-F SF Johnson M D MD Lin C-Y CY Hsiao P-W PW Lee M-S MS Lee M-S MS

Oncogene 20131014 38

Dysregulation of cell surface proteolysis has been strongly implicated in tumorigenicity and metastasis. In this study, we delineated the role of hepatocyte growth factor activator inhibitor-2 (HAI-2) in prostate cancer (PCa) cell migration, invasion, tumorigenicity and metastasis using a human PCa progression model (103E, N1, and N2 cells) and xenograft models. N1 and N2 cells were established through serial intraprostatic propagation of 103E human PCa cells and isolation of the metastatic cell ...[more]

PMID: 24121274

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