Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC4315710 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Chen Siqi S Wang Long L Fan Jie J Ye Cong C Dominguez Donye D Zhang Yi Y Curiel Tyler J TJ Fang Deyu D Kuzel Timothy M TM Zhang Bin B
Cancer research 20141210 3
miR155 is a regulator of immune cell development and function that is generally thought to be immunostimulatory. However, we report here that genetic ablation of miR155 renders mice resistant to chemical carcinogenesis and the growth of several transplanted tumors, suggesting that miR155 functions in immunosuppression and tumor promotion. Host miR155 deficiency promoted overall antitumor immunity despite the finding of defective responses of miR155-deficient dendritic cells and antitumor T cells ...[more]