Ontology highlight
ABSTRACT:
SUBMITTER: Jardon-Valadez E
PROVIDER: S-EPMC4315726 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20141201 12
Translocation of negatively charged ions across cell membranes by ion pumps raises the question as to how protein interactions control the location and dynamics of the ion. Here we address this question by performing extensive molecular dynamics simulations of wild type and mutant halorhodopsin, a seven-helical transmembrane protein that translocates chloride ions upon light absorption. We find that inter-helical hydrogen bonds mediated by a key arginine group largely govern the dynamics of the ...[more]