Nanofibrillar Peptide hydrogels for the immobilization of biocatalysts for chemical transformations.
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ABSTRACT:
SUBMITTER: Hickling C
PROVIDER: S-EPMC4316184 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Nanofibrillar Peptide hydrogels for the immobilization of biocatalysts for chemical transformations.
Hickling Christopher C Toogood Helen S HS Saiani Alberto A Saiani Alberto A Scrutton Nigel S NS Miller Aline F AF
Macromolecular rapid communications 20140307 9
Enzymes are attractive, "green" alternatives to chemical catalysts within the industrial sector, but their robustness to environmental conditions needs optimizing. Here, an enzyme is tagged chemically and recombinantly with a self-assembling peptide that allows the conjugate to spontaneously assemble with pure peptide to form β-sheet-rich nanofibers decorated with tethered enzyme. Above a critical concentration, these fibers entangle and form a 3D hydrogel. The immobilized enzyme catalyzes chemi ...[more]
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