Ontology highlight
ABSTRACT:
SUBMITTER: Kreusser MM
PROVIDER: S-EPMC4316667 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Kreusser Michael M MM Lehmann Lorenz H LH Keranov Stanislav S Hoting Marc-Oscar MO Oehl Ulrike U Kohlhaas Michael M Reil Jan-Christian JC Neumann Kay K Schneider Michael D MD Hill Joseph A JA Dobrev Dobromir D Maack Christoph C Maier Lars S LS Gröne Hermann-Josef HJ Katus Hugo A HA Olson Eric N EN Backs Johannes J
Circulation 20140814 15
<h4>Background</h4>Ca(2+)-dependent signaling through CaM Kinase II (CaMKII) and calcineurin was suggested to contribute to adverse cardiac remodeling. However, the relative importance of CaMKII versus calcineurin for adverse cardiac remodeling remained unclear.<h4>Methods and results</h4>We generated double-knockout mice (DKO) lacking the 2 cardiac CaMKII genes δ and γ specifically in cardiomyocytes. We show that both CaMKII isoforms contribute redundantly to phosphorylation not only of phospho ...[more]