Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4317007 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Li Xiaoli X Li Jie J Wilson Andrew A Sipple Jared J Schick Jonathan J Pang Qishen Q
The Journal of biological chemistry 20141212 5
Functional maintenance of hematopoietic stem cells (HSCs) is constantly challenged by stresses like DNA damage and oxidative stress. Here we show that the Fanconi anemia protein Fancd2 and stress transcriptional factor Foxo3a cooperate to prevent HSC exhaustion in mice. Deletion of both Fancd2 and Foxo3a led to an initial expansion followed by a progressive decline of bone marrow stem and progenitor cells. Limiting dilution transplantation and competitive repopulating experiments demonstrated a ...[more]