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Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling.

ABSTRACT: Solid phase synthesis of HBS helices involving the Fukuyama-Mitsunobu reaction and triphosgene coupling is described.

SUBMITTER: Patgiri A

PROVIDER: S-EPMC4317285 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling.

Patgiri Anupam A Witten Michael R MR Arora Paramjit S PS

Organic & biomolecular chemistry 20100401 8

Solid phase synthesis of HBS helices involving the Fukuyama-Mitsunobu reaction and triphosgene coupling is described. ...[more]

PMID: 20449477

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