Ontology highlight
ABSTRACT:
SUBMITTER: Bruedigam C
PROVIDER: S-EPMC4317339 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Cell stem cell 20141201 6
Acute myeloid leukemia (AML) is an aggressive and lethal blood cancer maintained by rare populations of leukemia stem cells (LSCs). Selective targeting of LSCs is a promising approach for treating AML and preventing relapse following chemotherapy, and developing such therapeutic modalities is a key priority. Here, we show that targeting telomerase activity eradicates AML LSCs. Genetic deletion of the telomerase subunit Terc in a retroviral mouse AML model induces cell-cycle arrest and apoptosis ...[more]