Ontology highlight
ABSTRACT:
SUBMITTER: Cheng CY
PROVIDER: S-EPMC4317498 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Cheng Ching-Yu CY Yamashiro Kenji K Chen Li Jia LJ Ahn Jeeyun J Huang Lulin L Huang Lvzhen L Cheung Chui Ming G CM Miyake Masahiro M Cackett Peter D PD Yeo Ian Y IY Laude Augustinus A Mathur Ranjana R Pang Junxiong J Sim Kar Seng KS Koh Adrian H AH Chen Peng P Lee Shu Yen SY Wong Doric D Chan Choi Mun CM Loh Boon Kwang BK Sun Yaoyao Y Davila Sonia S Nakata Isao I Nakanishi Hideo H Akagi-Kurashige Yumiko Y Gotoh Norimoto N Tsujikawa Akitaka A Matsuda Fumihiko F Mori Keisuke K Yoneya Shin S Sakurada Yoichi Y Iijima Hiroyuki H Iida Tomohiro T Honda Shigeru S Lai Timothy Yuk Yau TY Tam Pancy Oi Sin PO Chen Haoyu H Tang Shibo S Ding Xiaoyan X Wen Feng F Lu Fang F Zhang Xiongze X Shi Yi Y Zhao Peiquan P Zhao Bowen B Sang Jinghong J Gong Bo B Dorajoo Rajkumar R Yuan Jian-Min JM Koh Woon-Puay WP van Dam Rob M RM Friedlander Yechiel Y Lin Ying Y Hibberd Martin L ML Foo Jia Nee JN Wang Ningli N Wong Chang Hua CH Tan Gavin S GS Park Sang Jun SJ Bhargava Mayuri M Gopal Lingam L Naing Thet T Liao Jiemin J Ong Peng Guan PG Mitchell Paul P Zhou Peng P Xie Xuefeng X Liang Jinlong J Mei Junpu J Jin Xin X Saw Seang-Mei SM Ozaki Mineo M Mizoguchi Takanori T Kurimoto Yasuo Y Woo Se Joon SJ Chung Hum H Yu Hyeong-Gon HG Shin Joo Young JY Park Dong Ho DH Kim In Taek IT Chang Woohyok W Sagong Min M Lee Sang-Joon SJ Kim Hyun Woong HW Lee Ji Eun JE Li Yi Y Liu Jianjun J Teo Yik Ying YY Heng Chew Kiat CK Lim Tock Han TH Yang Suk-Kyun SK Song Kyuyoung K Vithana Eranga N EN Aung Tin T Bei Jin Xin JX Zeng Yi Xin YX Tai E Shyong ES Li Xiao Xin XX Yang Zhenglin Z Park Kyu-Hyung KH Pang Chi Pui CP Yoshimura Nagahisa N Wong Tien Yin TY Khor Chiea Chuen CC
Nature communications 20150128
Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 controls, all of East Asian descent, as part of The Genetics of AMD in Asians (GAMA) Consortium. We find a strong association between CETP Asp442Gly (rs2303790), an East Asian-specific mutation, and in ...[more]