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Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type.

ABSTRACT: Multidrug resistance (MDR) is considered a multifactorial event that favors cancer cells becoming resistant to several chemotherapeutic agents. Numerous mechanisms contribute to MDR, such as P-glycoprotein (Pgp/ABCB1) activity that promotes drug efflux, overexpression of inhibitors of apoptosis proteins (IAP) that contribute to evasion of apoptosis, and oncogenic pathway activation that favors cancer cell survival. MDR molecules have been identified in membrane microparticles (MP) and can be transferred to sensitive cancer cells. By co-culturing MP derived from MDR-positive cells with recipient cells, we showed that sensitive cells accumulated Pgp, IAP proteins and mRNA. In addition, MP promoted microRNA transfer and NF?B and Yb-1 activation. Therefore, our results indicate that MP can induce a multifactorial phenotype in sensitive cancer cells.

SUBMITTER: de Souza PS

PROVIDER: S-EPMC4317771 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type.

de Souza Paloma Silva PS Cruz André L S AL Viola João P B JP Maia Raquel C RC

Cancer science 20141215 1

Multidrug resistance (MDR) is considered a multifactorial event that favors cancer cells becoming resistant to several chemotherapeutic agents. Numerous mechanisms contribute to MDR, such as P-glycoprotein (Pgp/ABCB1) activity that promotes drug efflux, overexpression of inhibitors of apoptosis proteins (IAP) that contribute to evasion of apoptosis, and oncogenic pathway activation that favors cancer cell survival. MDR molecules have been identified in membrane microparticles (MP) and can be tra ...[more]

PMID: 25457412

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