Ontology highlight
ABSTRACT:
SUBMITTER: Nishikawa R
PROVIDER: S-EPMC4317931 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Nishikawa Rika R Goto Yusuke Y Sakamoto Shinichi S Chiyomaru Takeshi T Enokida Hideki H Kojima Satoko S Kinoshita Takashi T Yamamoto Noriko N Nakagawa Masayuki M Naya Yukio Y Ichikawa Tomohiko T Seki Naohiko N
Cancer science 20140618 7
Our recent studies of the microRNA (miRNA) expression signature in prostate cancer (PCa) indicated that miRNA-218 (miR-218) was significantly downregulated in clinical specimens, suggesting that miR-218 might act as a tumor-suppressive miRNA in PCa. The aim of the present study was to investigate the functional significance of miR-218 in PCa and to identify novel miR-218-regulated cancer pathways and target genes involved in PCa oncogenesis and metastasis. Restoration of miR-218 in PCa cell line ...[more]