LincRNA HOTAIR as a novel promoter of cancer progression.
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ABSTRACT:
SUBMITTER: Loewen G
PROVIDER: S-EPMC4318250 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
lincRNA HOTAIR as a novel promoter of cancer progression.
Loewen Gregory G Zhuo Ying Y Zhuang Yan Y Jayawickramarajah Janarthanan J Shan Bin B
Journal of cancer research updates 20140701 3
Large intergenic non-coding RNAs (lincRNA) regulate development and disease <i>via</i> interactions with their protein partners. Expression of the lincRNA HOX transcript antisense RNA (HOTAIR) is elevated in a variety of malignancies and linked to metastasis and poor prognosis. HOTAIR promotes proliferation, invasion, and metastasis in the preclinical studies of cancer through modulation of chromatin modifying complexes. In the current review we discuss the molecular mechanisms of HOTAIR-mediate ...[more]
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