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A barcode-free combinatorial screening platform for matrix metalloproteinase screening.

ABSTRACT: Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application.

SUBMITTER: Rane TD

PROVIDER: S-EPMC4318618 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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A barcode-free combinatorial screening platform for matrix metalloproteinase screening.

Rane Tushar D TD Zec Helena C HC Wang Tza-Huei TH

Analytical chemistry 20150114 3

Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application. ...[more]

PMID: 25543856

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