Unknown

Dataset Information

0

Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants.


ABSTRACT:

Background

BCG vaccination prevents disseminated tuberculosis in children, but it is contraindicated for persons with human immunodeficiency virus (HIV) infection because it can result in severe disease in this population. In tuberculosis-endemic regions, BCG vaccine is administered soon after birth, before in utero and peripartum HIV infection is excluded. We therefore assessed the immunogenicity of BCG vaccine in HIV-exposed infants who received BCG at birth or at 8 weeks of age.

Methods

HIV-exposed, uninfected infants were randomly assigned to receive BCG vaccination at birth (the early vaccination arm) or 8 weeks of age (the delayed vaccination arm). BCG-specific proliferative and intracellular cytokine responses were assessed in 28 infants per arm at 6, 8, and 14 weeks of life.

Results

There was no difference in BCG-specific T-cell proliferation between the study arms 6 weeks after vaccination. However, at 14 weeks of age, the frequency of interferon γ-expressing CD4(+) T cells and multifunctional BCG-specific responses in the delayed vaccinated arm were significantly higher than those in the early vaccination arm (P = .021 and P = .011, respectively).

Conclusions

The immunogenicity of BCG vaccination in HIV-exposed, uninfected infants is not compromised when delayed until 8 weeks of age and results in robust BCG-specific T-cell responses at 14 weeks of age. These findings support further evaluation of this modified BCG vaccination strategy for HIV-exposed infants.

Clinical trials registration

NCT02062580.

SUBMITTER: Tchakoute CT 

PROVIDER: S-EPMC4318913 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2745558 | biostudies-literature
| S-EPMC6392474 | biostudies-literature
| S-EPMC4562895 | biostudies-literature
| S-EPMC5374072 | biostudies-literature
| S-EPMC3552126 | biostudies-literature
| S-EPMC5374628 | biostudies-literature
| S-EPMC3738238 | biostudies-literature
| S-EPMC5106616 | biostudies-literature
2014-06-11 | E-GEOD-56559 | biostudies-arrayexpress
2014-06-11 | GSE56559 | GEO