Ontology highlight
ABSTRACT:
SUBMITTER: Guo C
PROVIDER: S-EPMC4319032 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20141217 6
Repression of peroxisome proliferator-activated receptor γ (PPARγ)-dependent transcription by the nuclear receptor corepressor (NCoR) is important for homeostatic expression of PPARγ target genes in vivo. The current model states that NCoR-mediated repression requires its direct interaction with PPARγ in the repressive conformation. Previous studies, however, have shown that DNA-bound PPARγ is incompatible with a direct, high-affinity association with NCoR because of the inherent ability of PPAR ...[more]