Ontology highlight
ABSTRACT:
SUBMITTER: Motelow JE
PROVIDER: S-EPMC4319118 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Neuron 20150201 3
Impaired consciousness in temporal lobe seizures has a major negative impact on quality of life. The prevailing view holds that this disorder impairs consciousness by seizure spread to the bilateral temporal lobes. We propose instead that seizures invade subcortical regions and depress arousal, causing impairment through decreases rather than through increases in activity. Using functional magnetic resonance imaging in a rodent model, we found increased activity in regions known to depress corti ...[more]