Ontology highlight
ABSTRACT:
SUBMITTER: Moon JS
PROVIDER: S-EPMC4319445 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Moon Jong-Seok JS Lee Seonmin S Park Mi-Ae MA Siempos Ilias I II Haslip Maria M Lee Patty J PJ Yun Mijin M Kim Chun K CK Howrylak Judie J Ryter Stefan W SW Nakahira Kiichi K Choi Augustine M K AM
The Journal of clinical investigation 20150109 2
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory responses remain unclear. The NLRP3 inflammasome serves as a platform for caspase-1-dependent maturation and secretion of proinflammatory cytokines. Here, we demonstrated that the mitochondrial uncoupling protein-2 (UCP2) regulates NLRP3-mediated caspase-1 activation through the stimulation of lipid synthesis in macrophages. UCP2-deficient ...[more]