Ontology highlight
ABSTRACT:
SUBMITTER: Szumowski JD
PROVIDER: S-EPMC4319680 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Szumowski John D JD Lynch John B JB
Drug design, development and therapy 20150129
New approaches to the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) are badly needed. Not only is the success rate of current treatment regimens suboptimal but existing regimens require multiple drugs and lengthy courses and may lead to significant toxicities. The treatment landscape is beginning to shift, however, with the recent approvals of the new TB drugs bedaquiline and delamanid. Delamanid, a dihydro-imidazooxazole, has been shown to have excellent acti ...[more]