Smart polymeric nanoparticles for cancer gene delivery.

ABSTRACT: The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral vectors to a level similar to viruses. This review serves as an introduction to surface modifications of NPs based on polymeric structural improvements and target moieties. A discussion regarding the future perspective of multifunctional NPs in cancer therapy is also included.

SUBMITTER: Lin G 

PROVIDER: S-EPMC4319689 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature