Ontology highlight
ABSTRACT:
SUBMITTER: Isobe A
PROVIDER: S-EPMC4319819 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Isobe Aki A Sawada Kenjiro K Kinose Yasuto Y Ohyagi-Hara Chifumi C Nakatsuka Erika E Makino Hiroshi H Ogura Tomonori T Mizuno Tomoko T Suzuki Noriko N Morii Eiichi E Nakamura Koji K Sawada Ikuko I Toda Aska A Hashimoto Kae K Mabuchi Seiji S Ohta Tsuyoshi T Morishige Ken-ichirou K Kurachi Hirohisa H Kimura Tadashi T
PloS one 20150206 2
Ovarian cancer remains the most lethal gynecologic cancer and new targeted molecular therapies against this miserable disease continue to be challenging. In this study, we analyzed the expressional patterns of Interleukin-6 (IL-6) and its receptor (IL-6R) expression in ovarian cancer tissues, evaluated the impact of these expressions on clinical outcomes of patients, and found that a high-level of IL-6R expression but not IL-6 expression in cancer cells is an independent prognostic factor. In in ...[more]