Ontology highlight
ABSTRACT:
SUBMITTER: Ciurea SO
PROVIDER: S-EPMC4320643 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ciurea Stefan O SO Mulanovich Victor V Saliba Rima M RM Bayraktar Ulas D UD Jiang Ying Y Bassett Roland R Wang Sa A SA Konopleva Marina M Fernandez-Vina Marcelo M Montes Nivia N Bosque Doyle D Chen Julianne J Rondon Gabriela G Alatrash Gheath G Alousi Amin A Bashir Qaiser Q Korbling Martin M Qazilbash Muzaffar M Parmar Simrit S Shpall Elizabeth E Nieto Yago Y Hosing Chitra C Kebriaei Partow P Khouri Issa I Popat Uday U de Lima Marcos M Champlin Richard E RE
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120711 12
Haploidentical stem cell transplantation (SCT) has been generally performed using a T cell depleted (TCD) graft; however, a high rate of nonrelapse mortality (NRM) has been reported, particularly in adult patients. We hypothesized that using a T cell replete (TCR) graft followed by effective posttransplantation immunosuppressive therapy would reduce NRM and improve outcomes. We analyzed 65 consecutive adult patients with hematologic malignancies who received TCR (N = 32) or TCD (N = 33) haploide ...[more]